Ana Itzel Nunez del Toro: Hippocampal ripple oscillations in an excitation-first network model with supralinear dendritic interactions

BCCN Berlin / Technische Universität Berlin

Abstract

 

The hippocampus and sleep are two main components related to the process of memory consolidation. It has been observed that during deep sleep and resting states, the hippocampus displays a type of oscillation referred to as sharp-wave ripple complexes. Furthermore, it was noticed that the area displaying the strongest ripple oscillation component (150-250 Hz) is CA1 and that the pyramidal cells here have nonlinear dendritic responses. The processes by which these complexes are being produced and the complete mechanisms that bind them together with the process of memory consolidation are still unclear. In this thesis, I replicate an excitation-first model based on a dendritic nonlinearity and chemical synapses in order to inspect the ripple component properties of the sharp-wave ripple complexes, as well as the dendritic influences in the network, and thus, be able to reproduce the phenomenon of intra-ripple frequency accommodation.

 

Additional Information

Master Thesis Defense

 

Organized by

Prof. Dr. Richard Kempter   & Dr. Nikolaus Maier     / Lisa Velenosi