BCCN Lecture Series feat. Brain Awareness Week - Talk by Momsen Reincke
CharitéCenter for Neurology, Neurosurgery and Psychiatry, Charité – Universitätsmedizin Berlin
Titel: Towards Antibody-omics: From Monoclonal Antibodies to Antigen-Specific Therapies
Abstract: Autoimmune encephalitides such as anti-NMDAR encephalitis illustrate how pathogenic surface-directed auto-antibodies can both explain disease and unlock targeted therapy. This talk traces the trajectory from broad immunosuppression to an antigen-specific strategy: NMDAR-selective CAAR-T cells that eradicate only the pathogenic B-cell clones, promising durable remission with fewer systemic risks. Building on that proof-of-concept, we outline an “Antibody-Omics” roadmap—high-throughput sequencing and structural profiling of autoreactive repertoires to predict epitope binding and pathogenicity directly from sequence data using a combination of wet-lab experimentation and artificial intelligence. By uniting precision cell therapy and AI-enabled antibody characterization, this sketches a future in which central-nervous-system autoimmunity is diagnosed faster, more precisely and treated with antigen-specific interventions.
Guests are welcome!
Organized by
Michael Brecht / Lisa Rosenbluhm
Location: BCCN Berlin, lecture hall 9, Philippstr. 13 Haus 6, 10115 Berlin
Date: 2026-03-25 at 16:00
Location: BCCN Berlin, lecture hall 9, Philippstr. 13 Haus 6, 10115 Berlin