Negin Zariei: Categorization of Vocalizations in an Autistic Mouse Model

BCCN Berlin / Technische Universität Berlin

Abstract

Fmr1-KO mice display symptoms like Fragile X syndrome (FXS) patients, i.e., acoustic hypersensitivity, and autistic behavior traits and is the most common hereditary form of mental disability in humans. It is shown that Fmr1-KO mice have aberrant vocal communications, and it persists into adulthood while courtship a female mouse. There are few numbers of studies working on grouping mouse vocalizations during courtship. However, there is no comprehensive approach to study the clusterability and clustering of the mouse vocalizations during courtship. This study aims to firstly check the clusterability of Fmr1-KO and wild type (WT) mouse vocalizations using different data. Secondly, Specify the categories of vocalizations of the fragile X mice in comparison to wild genotypes. Finally, check if the grouped vocalizations share specific acoustic properties and compare different clustering algorithms. I present a set of computational methods for analyzing vocalizations and clustering them.

 

Additional Information

Master Thesis Defense

 

Organized by

Prof. Ursula Koch   & Prof. Richard Kempter     / Lisa Velenosi